Perhaps a more exact title for this book might have been God and Reason in Medieval Universities, for its major focus is on the way that reason, especially in the form of logic and natural philosophy, became a permanently and pervasively established feature of human inquiry across the various faculties. Indeed the central thesis of the book is that despite the distorting characterizations of the Middle Ages as a period of faith at best and darkness at worst, it was actually (...) a period in which human reason achieved an unprecedented preeminence that was the necessary condition for the development of early modern science. According to Grant, “in all the history of human civilization, reason had never been accorded such a central role, one that involved so many people over such a wide area for such an extended period”. (shrink)

When Norman Kretzmann died in August of 1998, he left unfinished what was to have been a three volume presentation of Aquinas’s natural theology according to the first three books of the Summa contra gentiles. This second volume, the successor to The Metaphysics of Theism, thus stands as his final work. Kretzmann’s hope was to present Aquinas’s natural theology in such a way as to show its contemporary philosophical relevance and viability; it was not to be a historical reconstruction or (...) a commentary, but rather a critical appreciation or even a rethinking of Aquinas’s achievement. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Thomas Aquinas’s “Summa Theologiae”: A Guide and Commentary by Brian DaviesBrian J. Shanley, O.P.Thomas Aquinas’s “Summa Theologiae”: A Guide and Commentary. By Brian Davies, O.P. Oxford: Oxford University Press, 2014. Pp. xv + 454. $105.00 (cloth), $31.95 (paper). ISBN: 978-0-19-938062-6 (cloth), 978-0-19-938063-3 (paper).The purpose of this book is to provide guidance to a nonspecialist reader of Aquinas’s Summa theologiae. It is not meant as a (...) substitute for the text itself, but rather as a companion for a reader in order to offer explication for the most important arguments, a sense of the context of the whole, a quick survey of the terrain of a treatise, some historical context when necessary, and a prod to critical thinking. Davies’s ambition is daunting. As the subtitle indicates, he intends the book to be both a guide and a commentary. If it were only a guide, it would focus on the truly critical themes in some depth in order to aid the reader through the various parts without commenting on everything. If it were only a commentary, its purpose would be largely expository and exegetical. It is hard to do both functions well on a work as large and complex as the Summa theologiae.After a brief overview of Aquinas’s life and a short commentary on the meaning of sacra doctrina, Davies turns to the topic of God. Given his previous work on Aquinas, it is not surprising that the strongest and longest section of his book concerns the Prima pars. Davies does a nice job of parsing the existence of God and mapping out the Five Ways in a manner suitable to his audience. He then turns to the question of how God does not exist, and makes it plain that the main thrust of Aquinas’s treatment is apophatic, or negative. It is surprising that Davies never mentions the influence of Pseudo-Dionysius on Aquinas and generally downplays the Neoplatonic strains in Aquinas’s theology. I would have thought that divine simplicity and goodness deserve more consideration, and I would have liked to see Davies give more insight for the reader on how to parse some of Aquinas’s metaphysical terms (especially the real distinction in created beings and how this is the main marker of the ontological gap between God and creation). When Davies turns to how we name or use language about God, he signals to his readers that he is entering into an area that has been much debated. Not surprisingly, while he does a reasonable job of trying to explain how analogical predication works to a nonspecialist reader, specialists will have much to quibble about. At the heart of his explanation of analogy is the claim that analogy is primarily “a linguistic phenomenon in which one and the same word is used to speak of different things with connections of meaning that can be traced in each use of the word” (69). Analogy in Aquinas is more than a theory about language; it is embedded in a metaphysics of participation and creation that needs to be adumbrated to understand how analogy works. The subsequent treatment of God’s knowing and willing is reliable, though more attention might have been paid to the practical model of divine knowing. When it comes to the Trinity, [End Page 306] Davies does a solid job of trying to explain that most complicated doctrine of Aquinas to a nonspecialist.Davies misses the opportunity to explore the fundamental contrast that Aquinas draws between God’s causal immanence in all things as Creator and his special, interpersonal, Trinitarian indwelling through grace, as the treatise on the Trinity segues into the treatise on creation. When turning to creation, Davies notes that the fundamental metaphysical principle behind Aquinas’s account is that “the existence of something that does not exist by nature has to be caused” (110), although he seems diffident about its validity (“like it or not”) and never mentions participation. Sometimes he speaks about God’s causality in creation as “causally accounting for their esse” (ibid.) even as he notes that God... (shrink)

The contributors to the volume are Seth Benardete, Michael Gillespie, Leon Kass, Robert B. Pippin, Robert Rethy, John M. Rist, Brian J. Shanley, O. P., Susan ...

This collection originated in the centenary celebration of the School of Philosophy at The Catholic University of America. Written by experts in their fields, the essays are intended to provide a unique overview of philosophical developments in the 20th century. The first set of essays deals with philosophy in the English-speaking world. Thomas R. Russman argues that British philosophy is best understood as reflecting a long-standing preoccupation with the refutation of idealism. William Wallace narrates the development of the philosophy of (...) science. Peter Simpson provides an account of Anglo-American moral theory, and Robert George discusses Anglo-American legal philosophy. The second set of essays deals with developments within the Catholic world. Frederick Crosson offers an overview of a century of Catholic social teaching, focusing on the central question of the relationship between the policial and the moral in such figures as Maritain, Murray and MacIntyre. Timothy Noone reflects on the course of medieval scholarship and philosophy in the 20th century. Kenneth Schmitz contributes an authoritative overview of German Catholic thought in the last century. Richard Schenk introduces readers to one of the most significant German Catholic philosophers of the latter part of the 20th century, Robert Spaemann, and his ethics. Also included is Spaemann's own analysis of the relationship between Christianity and modern philosophy. A third set of essays concerns continental philsophy. Nicholas Lobkowicz debunks the idea that there was a powerful spell cast on German thought by Karl Marx, and shows instead that what passed for Marx's influence was really Left-Hegelianism. Robert Sokolowski provides a detailed treatment of a different strain of German thought in his overview of phenomenology. A final set of essays considers new areas of philosophical concern. Daniel Dahlstrom explores prominent developments in philosophy and art that have brought aesthetics to the center of philosophical inquiry. Eugene Long chronicles the burgeoning discipline of the philosophy of religion. In the concluding essay, A.S. Cua explores the ways in which western philosophy has influenced 20th-century Chinese philosophy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Évangile et Providence: Une théologie de l’action de Dieu by Emmanuel DurandMichael J. Dodds, O.P.Évangile et Providence: Une théologie de l’action de Dieu. By Emmanuel Durand. Paris: Cerf, 2014. Pp. 345. €35.00 (paper). ISBN: 978-2-204-10201-8.Emmanuel Durand offers a refreshing perspective on the question of divine action, so much discussed in recent years in the dialogue between theology and science. While not neglecting the fruit of that discussion, his (...) framing of the question under the headings of “Gospel” and “Providence” opens a new vista that is evident in his opening question: “What theology of Providence is needed today for the Gospel of salvation?” (7).Although contemporary theology readily affirms the biblical proclamation of God’s universal offer of salvation, its account of God’s salvific action on behalf of each person has become “uncertain and problematic.” Discussions of divine “kenosis, self-limitation, retreat, and powerlessness” have led many to the conviction God’s action must somehow be “limited” (8). The result is the paradox of a limited God attempting to offer universal salvation. The remedy lies in the recovery of a correct understanding of “the sovereignty of God”—the God who acts not only in the “intimacy of human hearts” but also in and through the “happy and unhappy contingencies” of human life (8-9).Durand begins by placing the question of divine action in the context of contemporary theology and culture, considering first the relationship between divine and human action, then the question of God’s action in history, and finally the understanding of divine action that has surfaced in the dialogue between theology and science (chap. 1). His next task is to clarify the notion of “action” itself. This entails an account of analogy (chap. 2). The discussion then turns to the “creative reappropriation” (10) of three classical theologies of divine providence, those of St. Augustine, St. Thomas Aquinas, and John Henry Newman. This involves a careful consideration of the Confessions of Augustine, the Summa contra gentiles of Aquinas, and the sermons of Newman (chaps. 3-5).The flip side of the question of divine action is of course the problem of evil and why a God who is capable of overcoming evil does not do so. Durand proposes not to “resolve” (résoudre) such problems here, but simply to help us “press” (serrer) them (11) as a preparation for listening to what revelation may say of them (chap. 6). The question of evil serves as the background for the discussion of Scripture that follows, where aspects of the books of Wisdom, Luke, and John are considered (chap. 7). Durand concludes with a [End Page 133] constructive proposal for understanding Providence in the world as we find it today, afflicted with evil (chap. 8).Durand begins his book with a discussion of the widespread opinion in contemporary philosophy and theology that divine and human action are somehow opposed to or in competition with each other. He traces this notion to Sartre, arguing that it now seems to pervade our culture despite the efforts of theologians such as Sertillanges to refute it. God’s action in the world is thought to diminish as humanity matures historically. The sovereign God gives place to the suffering God, who can act only through the actions of humans. The contemporary notion of history itself poses problems for divine action. It is difficult to affirm God’s saving and directing action in history, when history itself has lost its direction: “The loss of confidence in the intelligibility of history also jeopardizes the representation of God as sovereign, cause, author, director or guarantor of history” (29). Finally, the ability of science to explain natural events has led some to the conviction that there is simply no room for God to act in the world without interfering with the order of scientific laws. Durand presents a fine summary and critique of the responses to this dilemma that have surfaced in the ongoing dialogue between theologians and scientists, especially under the auspices of the Center for Theology and the Natural Sciences at the Graduate Theological Union in Berkeley (31-60).Durand... (shrink)

This slender volume is a polemical work on two fronts. First and foremost, it is an attempt to distinguish sharply the aim of Aquinas from that of post-Cartesian rationalism with respect to the role of philosophical argumentation in establishing the existence of God. Cartesian rationalism holds that it is possible to articulate presuppositionless, universal, compelling, and purely philosophical reasons to justify a foundational belief in God. Velecky criticizes this view on Wittgensteinian grounds and holds that there are significant affinities between (...) Aquinas and Wittgenstein on the relationship between religious belief and philosophical justification. What counts as a good philosophical case for the existence of God is always relative to the existential situation of the inquirer. So-called proofs for the existence of God are really attempts to formulate corroborating intellectual grounds for a belief that one has already come to on the basis of God's self-revelation, faith, and personal encounter. Belief in the proposition "that God exists" is not a statement reporting the existence of an item encounterable in our normal experience or the conclusion of an argument, but rather expresses the adoption of an entirely distinct perspective on the whole of reality. So when Aquinas describes arguments for the existence of God as preambula fidei, he does not mean that they are prior to faith as epistemologically necessary conditions for belief, but rather that they are logically required by faith in a different sense. It must be possible to locate or refer to the object of religious belief within a universe of philosophical discourse; or, to put it another way, it must be possible to give some content to the notion of divinity. The function of Aquinas's arguments is thus to make the proposition Deum esse intelligible within the universe of broadly Aristotelian discourse. This is especially important if believers want to have any kind of conversation with nonbelievers. Velecky writes: "At the conclusion of the Five Arguments nothing more--and nothing less--has been achieved than that a reasonable philosophical case has been made for a topic of conversation between Christians and others about the basic characterization of something which is thought to be the transcendent cause of all beings and which has left some traces of its transcendence in the world we can experience". Velecky's Wittgensteinian reading of Aquinas is a welcome antidote to the more usual Cartesian reading. But while Velecky is careful to distinguish Aquinas from Wittgensteinian fideism, nevertheless his overall strategy comes dangerously close to pushing Aquinas too far in that direction; Aquinas is neither Cartesian nor Wittgensteinian. (shrink)

This book is the first installment in a projected three volume critical analysis and creative appropriation of Aquinas’s natural theology in Summa contra gentiles I–III. The target audience seems to be contemporary Anglo-American philosophers of religion. Kretzmann wants to promote a greater integration of philosophy and theology through the pursuit of a metaphysics of theism. He claims that theology and philosophy both offer versions of a “Grandest Unified Theory” and what he proposes in this volume is a theology from the (...) bottom up that will establish what can be known of God through reason alone, in order subsequently to pursue a metaphysics from the top down that will begin with God and show the relationship of everything else to God. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 717 the work of Arthur Danto. Here the stimulus to reflection is those elements in modern art which " make a farce of traditional art and art theories hy giving us artworks indiscernible from objects found on grocery shelves or in lavatories." If, as Danto suggests, whatever is to count as art is simply what an " artworld " decrees, then the distinction between artefact and artwork (...) can disappear completely (except in terms of somebody's bank balance). The trouble with the remaining essays in this collection is that their authors have not appropriated a truth given lapidary expression in Woods' essay on Kant: "Attention to the works of genius throughout the ages cultivates the sensus communis and establishes a community involved in the beautiful." Thus, while Ted Cohen is right to consider television a possible artistic medium, the objects of televisual appreciation he considers usually witness to a breakdown of a community involved in the beautiful, while the frequently nugatory objects discussed in John Brough's "Who's Afraid of Marcel Duchamp? " testify to the disintegration of the sensus communis concerned. Finally, if Paul Weiss is right in his "Creativity and Beauty" not only to designate beauty " the excellence pertinent to the creation of a work of art," but also to house it together with the quartet of truth, goodness, glory, and justice, then we can get a sense of how wisdom in both philosophy and artistic practice might he restored: through a re· discovery of the interdependence of the transcendentals. But perhaps only the Judaeo-Christian revelation now holds the key to this possibility. AIDAN NICHOLS, O.P. Blackfriars Cambridge, England Through the Tempest: Theological Voyages in a Pluralistic Culture. By LANGDON GILKEY. Ed. Jeff B. Pool. Minneapolis: Fortress Press, 1991. Pp. xx + 252. Langdon Gilkey: Theologian for a Culture in Decline. By BRIAN J. WALSH. Lanham, MD: University Press of America/Institute for Christian Studies, 1991. Pp. xii + 324. $47.50 (cloth); $22.50 (paper). With the exception of two mid-1970s papers, Through the Tempest is a collection of some of the addresses and essays written in the 1980s hy Langdon Gilkey, Shailer Mathews Professor Emeritus at the University of Chicago Divinity School. Title and subtitle are meant to re· 718 BOOK REVIEWS fleet three elements of Gilkey's temper. First, the tempest corresponds to his dramatic vision of the twentieth-century world, with its wars, up· heavals, and destructive forces. Second, the preposition through expresses the sober hope that for all the darkness that surrounds our century, we are actually moving toward a destination beyond the turmoil. And third, his explorations and assessments of the many facets of contemporary culture are theological voyages. In these pages readers will find many of the themes Gilkey has tackled over the years, such as God, Jesus, Creation, Providence, spirituality, the function of symbols, ethics, suffering and death, Christianity and other religions, faith and science, church and public policy. Among the most original pieces are, to my mind, Ch. 10, on the different attitudes to ethics in Christianity and Buddhism, and Ch. 14, which clarifies many aspects of suffering. The general readership made up of those interested in religion will probably enjoy these lectures, while specialists in theology or human studies are likely to find them merely impressionistic and too vague both in their cultural analyses and in their conceptual discussions. Further, there is a discrepancy between Gilkey's assessment of the human predicament and :the theological solutions he puts forward. On the one hand, the mood and the content of his assessment is neo· orthodox (inspired by his master Reinhold Niebuhr). For instance, chapters 11 and 13, on evil and sin, are typical of an acute awareness of the dark side of human conduct. As he follows this vein, Gilkey raises pertinent, profound, and difficult questions. On :the other hand, his prescriptions do not match the depth of his diagnoses. Despite his efforts at overcoming theological liberalism, he often remains confined within the limits of the Western Enlightenment. For example, like most eighteenth-century thinkers, he rejects "a level of grace beyond nature " (54). What he repudiates is in all likeliness the modern separation between nature and supernature, and... (shrink)

Clarke acknowledges in his collected essays that he is a "Thomistically inspired" metaphysician rather than simply "Thomistic," because his principal aim is the creative retrieval and completion of Aquinas's metaphysics in the light of contemporary thought. Self-styled Thomists will inevitably and justifiably contest some of Clarke's creative completions of Aquinas, preferring the original to the interpretation, yet they can learn from his efforts at retrieval. While Clarke claims that his main interest is not historical exposition, two early essays show him (...) eminently capable of such writing. One is a classic exposition of how Aquinas transformed the Aristotelian act-potency theory to do the work of explaining the metaphysical composition of esse and essentia within a Neoplatonically inspired participation schema wherein act is considered to be intrinsically unlimited. The second is a general account of participation in Aquinas which displays Clarke's early assimilation of this central theme and his deep grounding in the European scholarship that transformed the landscape of Thomism at the midpoint of this century. (shrink)

OBJECTIVE: This article describes a method for investigating attitudes towards prioritisation in medicine. SETTING: University of Kuopio, Finland. DESIGN: The method consisted of a set of 24 paired scenarios, which were imaginary patient cases, each containing three different ethical indicators randomly selected from a list of indicators (for example, child, rich patient, severe disease etc.). The scenarios were grouped into 12 random pairs and the procedure was repeated four times, resulting in 12 scenario pairs arranged randomly in five different sets. (...) SURVEY: This method was tested with four groups of subjects (n = 8, n = 47, n = 104 and n = 36). RESULTS: Children and patients with a severe disease were prioritised in all groups. The aged, patients with a mild disease and patients with a self-acquired disease were negatively prioritised in all groups. Poor or rich patients were prioritised in some groups but negatively prioritised in others. CONCLUSIONS: The validity and reliability of this method are good and it is suitable for investigating attitudes towards medical prioritisation. (shrink)

CHAPTER ONE Augustine the Philosopher There are, according to Augustine in the early work entitled soliloquia, two principal (indeed, strictly speaking, ...

In lieu of an abstract, here is a brief excerpt of the content:308 BOOK REVIEWS lronioally, the retrieval of patristic theology together with the ecumenical emphasis has blunted some of the more "traditional" (i.e., Tridentine) Catholic accents within what used to be the most distinctively Catholic of the systematic treatises-church and sacraments. For example, while Power asserts the Eucharist as a real presence and propitiatory sacrifice (Tridentine themes), he does not stress them, in order to make room for an understanding (...) of the Eucharist as active celebration and sacramental memorial (Catholic themes older than Trent which are ecumenical at the same time) ; he also does not underscore the Tridentine teaching about the sacramental character of Orders and thus does not accentuate the difference between clergy and laity. Again, instead of offering a Tridentine critique of Luther's singular understanding of the fides sacramenti, especially as it applies to the sacra· ment of penance (according to the early Luther's erstwhile debate partner, Cardinal Cajetan, Luther's view of the fides sacramenti was the only thesis of his which could not be reconciled with the Catholic faith and in effect amounted to the founding of a new church), Duffy attempts to integrate its positive aspects within a Roman Catholic sacramentology. Systematic Theology is a work permeated by Catholic themes, even if some of them would have been handled differently by other Catholic authors and though some of them are also shared by Protestant authors. The two volumes are a worthwhile and solid introduction to and summary of the present state of Catholic theology in North America, at least from the centrist-liberal perspective, and will serve their intended audience very well. Domimican House of Studies Oakland, California GREGORY RoccA, O.P. The Glory of the Lord: A Theological Aesthetics. Vol. V: The Realm of Metaphysics in the Modern Age. By HANS URS VoN BALTHASAR. Translated by Oliver Davies, Andrew Louth, Brian McNeil C.R.V., John Saward and Rowan Williams. Edited by Brian McNeil C.R.V. and John Riches. San Francisco: Ignatius Press, 1991. Pp. 666. This volume of the English translation of Hans Urs von Balthasar's masterpiece comprises the latter half of Herrlichkeit, Band III/I, Im Raum der Metaphysik, the first half having been published as The Glory of the Lord, Volume IV: The Realm of Metaphysics in Antiquity. The BOOK REVIEWS 309 reader must remember that von Balthasar intends to denote by " metaphysics " the entire cultural complexus of myth, philosophy and religion, whose theological interest for von Balthasar is that it is seen to be the humanist anticipation of Glory, a grace-driven quest for God. This usage is of course unfamiliar to most students of the subject, and is one which moreover carries with it the anti-systematic presuppositions already noted in reviews of earlier volumes of The Glory of the Lord:* Von Balthasar looks upon " the realm of metaphysics " as that historical space in which the quest for human transcendence discovers that its goal is actual only in the Form of Christ, the Glory of God. The quest that is metaphysics is of itself a merely human project, and as such, is an illustration of human indigence. It is worth observing that von Balthasar's discussion of metaphysics, running to a thousand dense pages in the first (1965) edition of Band III/I: Im Raum der Metaphysik, has been considered dispensable to the unity of the Herrlichkeit by the editors of the French and Italian translations, both of which editions omit Band IH/L The English translation of its second part, here under review, makes that omission understandable, for in the first place its contribution to the whole is largely ancillary, a matter of illustration, and in the second, it is a work extraordinarily demanding of the reader-and if one may judge from the profusion of floating prepositions and consequent ambiguities in the English text, all too demanding of the translators as well. The sheer time required adequately to appreciate the prodigious learning of this massive study, and the patience required to keep its line of argument clear, are such as to defeat its purpose for most prospective readers. It is a work which, even more than the other volumes of The Glory... (shrink)

"O'Meara masterfully situates Pryzwara in relation to the traditional and contemporary theological, philosophical, ecclesial, cultural, and social contexts within which he wrote." --_William P. Loewe, professor of religious studies, Catholic University of America_ Erich Przywara, S.J. is one of the important Catholic intellectuals of the twentieth century. Yet, in the English-speaking world Przywara remains largely unknown. Few of his sixty books or six hundred articles have been translated. In this engaging new book, Thomas O'Meara offers a comprehensive study of the (...) German Jesuit Erich Przywara and his philosophical theology. Przywara's scholarly contributions were remarkable. He was one of three theologians who introduced the writings of John Henry Cardinal Newman into Germany. From his position at the Jesuit journal in Munich, _Stimmen der Zeit_, he offered an open and broad Catholic perspective on the cultural, philosophical, and theological currents of his time. As one of the first Catholic intellectuals to employ the phenomenologies of Edmund Husserl and Max Scheler, he was also responsible for giving an influential, more theological interpretation of the Spiritual Exercises of Ignatius Loyola. Przywara was also deeply engaged in the ideas and authors of his times. He was the first Catholic dialogue partner of Karl Barth and Paul Tillich. Edmund Husserl was counted among Przywara's friends, and Edith Stein was a close personal and intellectual companion. Through his interactions with important figures of his age and his writings, ranging from speculative systems to liturgical hymns, Przywara was of marked importance in furthering a varied dialogue between German Catholicism and modern culture. Following a foreword by Michael Fahey, S.J., O'Meara presents a chapter on Pryzwara's life and a chronology of his writings. O'Meara then discusses Pryzwara's philosophical theology, his lecture-courses at German universities on Augustine and Aquinas, his philosophy of religion, and his influence on important intellectual contemporaries. O'Meara concludes with an in-depth analysis of Pryzwara's theology, focusing particularly on his Catholic views of person, liturgy, and church. (shrink)

At the beginning of Sein und Zeit, Martin Heidegger raises the question “What is the meaning of Being?”. In a celebrated review of Heidegger, Gilbert Ryle observes that, though some would quarrel with the assumption “that there is a problem about the Meaning of Being,” he, for the moment, will not. Why not? Because, says Ryle, the “question of the relation between Being qua timeless ‘substance’ and existing qua existing in the world of time and space seems to me a (...) real one.”. (shrink)

New Blackfriars, Volume 103, Issue 1106, Page 433-435, July 2022.

New Blackfriars, Volume 103, Issue 1104, Page 165-169, March 2022.

Donald Gelpi, SJ saw his life's work as an attempt to construct an integral systematic theology during a time when such projects were deemed passé and undesirable. Such attitudes did not deter him though, and he worked quietly in his office at the Jesuit School of Theology in Berkeley for several decades developing such a system and teaching it in his classes and lectures. During those years, he produced works on theological method, sacramental theology, the Trinity, and Christology.Grounding his systematic (...) theology was a theological method defined by his fellow North American Jesuit, Bernard Lonergan. In his seminal work, Method in Theology, Lonergan articulated eight "functional specialties" for... (shrink)

Exposure of man to chemical agents can occur intentionally, as in the treatment of disease, or inadvertently because the environment contains a wide range of synthetic or naturally occurring chemicals. The alkylating agents are a diverse group of compounds (Fig. 1) and comprise a good example of such xenobiotics, since much is known about their occurrence, and their biological effects include carcinogenicity, mutagenicity, toxicity and teratogenicity.Exposure to potentially carcinogenic alkylating agents such as nitrosamines may occur occupationally, from cigarette smoke, from (...) certain foodstuffs and even endogenously through the ingestion of the appropriate precursor chemicals.1 At the other extreme, the cytotoxic effects of agents such as the chloroethylating nitrosamides or mustards have been exploited in the design of certain antitumour drugs.2 The effectiveness of antitumour agents and the other, mostly adverse, biological effects of alkylating agents have been ascribed to their ability to damage cellular macromolecules, in particular DNA. This review concentrates on investigations carried out over the past two years on the role of DNA damage in carcinogenesis, but we shall see how recent advances in this area of research have also led to a better understanding of the mechanisms of the cytotoxic effects of alkylating antitumour agents. (shrink)